Ignore Pain
This is A MUST skill. You just have to pick it, if you do not, than you will fail badly (unless you picked other survival ability with relatively low cooldown, that is Leap with Iron Impact, in fact it is better if you got not that great dps, but high amount of armor meaning 9k+). 65% reduced DMG is godly and will help you survive all the time. As for runes, all of them are useful in some ways. I would suggest picking up Ignorance is Bliss, if you have relatively good damage output. You will be surprised when you see the amount of self heal you can put off with that rune.
